Open the can of biscuits. Split each biscuit in half, so you end up with 16 dough pieces.
Add 1 cube of cheese and some chopped pepperoni to each biscuit.
Pull the sides of the biscuit up and pinch them together to secure.
Place pepperoni pizza bites into the air fryer basket so they are not touching. You might have to do two sets, depending on the size of your air fryer.
Baste the tops of the pizza bombs with the melted butter using a pastry brush. Sprinkle with Italian seasoning.
Cook in the air fryer at 350ºF for 6 minutes. Time may vary depending on your machine so check them at 5 minutes. Remove pizza bites from air fryer when the tops are a deep golden brown and they are baked through.
Let them cool for a few minutes before eating.