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close up of john wayne casserole.
5 from 4 votes

Easy John Wayne Casserole Recipe


Course Main Dish
Cuisine American, Mexican
Prep Time 15 minutes
Cook Time 40 minutes
Total Time 55 minutes
8 servings
This amazing Tex-Mex casserole combines layers of ground beef, biscuits and cheese to a delicious family meal everyone will love. It has been around for decades because it's just that good!

Equipment

  • large skillet
  • kitchen spatula
  • mixing bowls
  • 9x13in baking dish

Ingredients
  

  • cups Bisquick
  • cup water
  • 1 lb ground beef
  • ½ medium yellow onion diced, about 1 cup
  • 1 red bell pepper sliced
  • 10 oz Rotel tomatoes undrained
  • ¼ cup taco seasoning or 1 package
  • ½ cup sour cream plus more for serving
  • ½ cup mayonnaise
  • cups medium cheddar cheese shredded and divided

Optional Garnish:

  • chopped fresh cilantro
  • sour cream
  • diced tomatoes
  • sliced black olives

Instructions

  • Firstly grease a 9x13 casserole dish with nonstick cooking spray. Then, preheat the oven to 350 degrees Fahrenheit.
  • Brown ground beef and chopped onion in a large skillet over medium-high heat until no pink remains and onions have softened.
    raw ground beef and chopped onions in a skillet
  • Add the taco seasoning to the meat mixture and stir well.
    adding the taco seasoning to browned meat and onions
  • Then add Rotel tomatoes with all the juices and stir to combine. Set meat mixture aside.
    adding Rotel to browned taco meat
  • Afterward mix together biscuit mix and water in a large bowl until a shaggy dough forms.
    bisquick mix and water in a mixing bowl
  • Then add the cheese and form a cohesive dough.
    bisquick, water and cheese in a mixing bowl
  • Afterward press the biscuit layer evenly into a glass baking dish.
    biscuit mixture pressed into casserole dish
  • Then add the ground beef mixture on top of the bisquick layer. Make sure to spread it out evenly.
    beef mixture added to the top of the biscuit layer
  • In a separate bowl, stir together sour cream, mayonnaise, and 1 cup of grated cheese.
    sour cream mixture in a glass bowl
  • Then spread the sour cream mixture over the lean ground beef layer.
    sour cream mixture spread over taco meat layer
  • Top the casserole with the sliced bell peppers and the remaining cheese.
    cheese spread on top of john wayne casserole
  • Bake in the preheated oven for 30-40 minutes, until casserole is bubbly and the cheese is melted.
    cooked john wayne casserole

Notes

  • You can top each slice of John Wayne casserole with a dollop of sour cream, some diced tomatoes, black olives and chopped cilantro. 
  • Salsa, pico de gallo and guacamole are also great sides with this casserole. 

Nutrition

Calories: 583kcal | Carbohydrates: 30g | Protein: 22g | Fat: 42g | Saturated Fat: 16g | Polyunsaturated Fat: 8g | Monounsaturated Fat: 14g | Trans Fat: 1g | Cholesterol: 91mg | Sodium: 1395mg | Potassium: 364mg | Fiber: 3g | Sugar: 8g | Vitamin A: 1655IU | Vitamin C: 26mg | Calcium: 350mg | Iron: 3mg

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