Preheat the oven to 375°. Line your baking sheet with parchment paper to prevent the calzones from sticking to your pan.
Divide the pizza dough into two. Roll each into a ball. Roll out each piece to be about 8 inches in diameter.
Layer half the pepperoni, sausage, salami, and mozzarella cheese on each dough. We like to put a little cheese between each meat layer.
Top with half the mozzarella cheese.
Fold calzone over and pinch edges together. Roll pinched edges up and pinch again.
Make an egg wash in a small mixing bowl by whisking together the egg and water. Brush the egg wash over the top and sides of the calzones.
Sprinkle the top of each calzone with ⅛ teaspoon salt and ¼ teaspoon Italian seasoning. Optional: sprinkle with ⅛ teaspoon of garlic powder on each calzone.
Transfer both calzones to the parchment paper covered baking sheet.
Loosely tent the baking sheet with foil. Bake covered for 15 minutes. Remove foil and bake for another 15 minutes or until the crust of the calzone is a deep golden brown.
Serve with an Italian salad and marinara dipping sauce.